An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.

ABSTRACT: Odor detection applications are needed by human societies in various circumstances. Rodent offers unique advantages in developing biologic odor detection systems. This report outlines a novel apparatus designed to train maximum 5 mice automatically to detect odors using a new olfactory, relative go no-go, operant conditioning paradigm. The new paradigm offers the chance to measure real-time reliability of individual animal's detection behavior with changing responses. All of 15 water-deprivation mice were able to learn to respond to unpredictable delivering of the target odor with higher touch frequencies via a touch sensor. The mice were continually trained with decreasing concentrations of the target odor (n-butanol), the average correct percent significantly dropped when training at 0.0

SUBMITTER: He J 

PROVIDER: S-EPMC4421860 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature