Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes.

ABSTRACT: Histopathologic knowledge that extensive heterogeneity exists between and within tumors has been confirmed and deepened recently by molecular studies. However, the impact of tumor heterogeneity on prognosis and treatment remains as poorly understood as ever. Using a hybrid multiscale mathematical model of tumor growth in vascularized tissue, we investigated the selection pressures exerted by spatial and temporal variations in tumor microenvironment and the resulting phenotypic adaptations. A key component of this model is normal and tumor metabolism and its interaction with microenvironmental factors. The metabolic phenotype of tumor cells is plastic, and microenvironmental selection leads to increased tumor glycolysis and decreased pH. Once this phenotype emerges, the tumor dramatically c

SUBMITTER: Robertson-Tessi M 

PROVIDER: S-EPMC4421891 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature