BMP2 response pattern in human lung fibroblasts predicts outcome in lung adenocarcinomas.

ABSTRACT:

Background

Bone morphogenetic proteins play important roles in development, morphogenesis and cancer. With this study we aimed to characterize the response of lung stromal fibroblasts to BMPs and their antagonists on a genome wide level and investigate its potential role in human lung adenocarcinomas.

Methods

We used an ex vivo culture model and measured gene expression changes in human lung fibroblasts after stimulation with BMPs and their antagonists using HEEBO microarrays. The in vitro data were correlated with in vivo observations in published expression datasets of human lung adenocarcinomas.

Results

We have systematically analyzed the response to BMP2, BMP4, BMP7 and their antagonists, Gremlin and Noggin, to define common and specific gene expression patterns.

SUBMITTER: Rajski M 

PROVIDER: S-EPMC4422073 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature