Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes.

ABSTRACT:

Background

The variant rs11085226 (G) within the gene encoding polypyrimidine tract binding protein 1 (PTBP1) was reported to associate with reduced insulin release determined by an oral glucose tolerance test (OGTT) as well as an intravenous glucose tolerance test (IVGTT). The aim of the present study was to validate the association of the rs11085226 G-allele of PTBP1 with previously investigated OGTT- and IVGTT-derived diabetes-related metabolic quantitative phenotypes, to conduct exploratory analyses of additional measures of beta-cell function, and to further investigate a potential association with type 2 diabetes.

Methods

PTBP1 rs11085226 was genotyped in 20,911 individuals of Danish Caucasian ethnicity ascertained from 9 study samples. Case control analysis was perfor

SUBMITTER: Hansen TH 

PROVIDER: S-EPMC4422140 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature