The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity.

ABSTRACT:

Background

An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.

Methods

Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.

Results

The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much hig

SUBMITTER: Frisoni GB 

PROVIDER: S-EPMC4422168 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature