Brain and behavioral evidence for altered social learning mechanisms among women with assault-related posttraumatic stress disorder.

ABSTRACT: Current neurocircuitry models of PTSD focus on the neural mechanisms that mediate hypervigilance for threat and fear inhibition/extinction learning. Less focus has been directed towards explaining social deficits and heightened risk of revictimization observed among individuals with PTSD related to physical or sexual assault. The purpose of the present study was to foster more comprehensive theoretical models of PTSD by testing the hypothesis that assault-related PTSD is associated with behavioral impairments in a social trust and reciprocity task and corresponding alterations in the neural encoding of social learning mechanisms. Adult women with assault-related PTSD (n = 25) and control women (n = 15) completed a multi-trial trust game outside of the MRI scanner. A subset of these partici

SUBMITTER: Cisler JM 

PROVIDER: S-EPMC4422332 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature