Large-scale analysis of the evolutionary histories of phosphorylation motifs in the human genome.

ABSTRACT:

Background

Protein phosphorylation is a post-translational modification that is essential for a wide range of eukaryotic physiological processes, such as transcription, cytoskeletal regulation, cell metabolism, and signal transduction. Although more than 200,000 phosphorylation sites have been reported in the human genome, the physiological roles of most remain unknown. In this study, we provide some useful datasets for the assessment of functional phosphorylation signaling using a comparative genome analysis of phosphorylation motifs.

Findings

We described the evolutionary patterns of conservation of these and comparative genomic data for 93,101 phosphosites and 1,003,756 potential phosphosites in human phosphomotifs, using 178 phosphomotifs identified in a previous study t

SUBMITTER: Yoshizaki H 

PROVIDER: S-EPMC4422407 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature