Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?

ABSTRACT:

Background

Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.

Methods

We investigated the regulation of CLU transcript variants expression in an in vivo model system consisting of both neoplastic tissues and fine needle aspiration biopsy (FNAB) samples isolated from patients undergoing thyroidectomy.

Results

The immunohistochemical analyses showed an overall CLU up-regulation in papillary carcinoma. A specific CLU2 transcript variant increase was registered using qPCR in papillary carcinomas while CLU1 decreased. In addition, the analysis of CLU transcripts expression level showed an increase of the CLU2 transcript in

SUBMITTER: Fuzio P 

PROVIDER: S-EPMC4422431 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature