Validation study of candidate single nucleotide polymorphisms associated with left ventricular hypertrophy in the Korean population.

ABSTRACT:

Background

Left ventricular hypertrophy (LVH) is a valid predictor for cardiovascular mortality and morbidity regardless of age, gender, and race. The HyperGEN study conducted a genome-wide association study and identified twelve single nucleotide polymorphisms (SNPs) associated with LVH. The aim of this study was to validate these candidate SNPs in the Korean population.

Methods

Among 1637 individuals from the Korean Multi-Rural Communities Cohort Study (MRCohort) of the Korean Genome Epidemiology Study (KoGES), we carried out a linear regression analysis with left ventricular mass index (LVMI) and a logistic regression analysis for LVH status.

Results

The rs4129218 on chromosome 12 tended to be associated with LVM/body surface area (adjusted β = -0.023; p = 0.036) a

SUBMITTER: Park JK 

PROVIDER: S-EPMC4422470 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature