BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma (MM) arises from mesothelial cells that line the pleural, peritoneal and pericardial surfaces. The majority of MMs are pleural and have been associated with asbestos exposure. Previously, pleural MMs have been genetically characterized by the loss of BAP1 (40-60%) as well as loss of NF2 (75%) and CDKN2A (60%). The rare peritoneal form of MM occurs in ~10% cases. With only ~300 cases diagnosed in the US per year, its link to asbestos exposure is not clear and its mutational landscape unknown.

Methods

We analyzed the somatic mutational landscape of 12 peritoneal MM of epitheloid subtype using copy number analysis (N = 9), whole exome sequencing (N = 7) and targeted sequencing (N = 12).

Results

Peritoneal MM display few copy number alter

SUBMITTER: Alakus H 

PROVIDER: S-EPMC4422481 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature