Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach.

ABSTRACT: By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the suprachiasmatic nucleus (SCN) controls peripheral clocks that are present in virtually every body cell. Defective circadian timing is associated with several pathologies such as cancer and metabolic and sleep disorders. To better understand the circadian regulation of cellular processes, we developed a bioinformatics pipeline encompassing the analysis of high-throughput data sets and the exploitation of published knowledge by text-mining. We identified 118 novel potential clock-regulated genes and integrated them into an existing high-quality circadian network, generating the to-date most co

SUBMITTER: Lehmann R 

PROVIDER: S-EPMC4422523 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature