Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk.

ABSTRACT:

Background

Many epidemiology studies report that atopic conditions such as allergies are associated with reduced pancreas cancer risk. The reason for this relationship is not yet understood. This is the first study to comprehensively evaluate the association between variants in atopy-related candidate genes and pancreatic cancer risk.

Methods

A population-based case-control study of pancreas cancer cases diagnosed during 2011-2012 (via Ontario Cancer Registry), and controls recruited using random digit dialing utilized DNA from 179 cases and 566 controls. Following an exhaustive literature review, SNPs in 180 candidate genes were pre-screened using dbGaP pancreas cancer GWAS data; 147 SNPs in 56 allergy-related immunologic genes were retained and genotyped. Logistic regressi

SUBMITTER: Cotterchio M 

PROVIDER: S-EPMC4422524 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature