Neutrophils promote the malignant glioma phenotype through S100A4.

ABSTRACT:

Purpose

Antiangiogenic therapy is effective in blocking vascular permeability, inhibiting vascular proliferation, and slowing tumor growth, but studies in multiple cancer types have shown that tumors eventually acquire resistance to blockade of blood vessel growth. Currently, the mechanisms by which this resistance occurs are not well understood.

Experimental design

In this study, we evaluated the effects of neutrophils on glioma biology both in vitro and in vivo and determined target genes by which neutrophils promote the malignant glioma phenotype during anti-VEGF therapy.

Results

We found that an increase in neutrophil infiltration into tumors is significantly correlated with glioma grade and in glioblastoma with acquired resistance to anti-VEGF therapy. Our data d

SUBMITTER: Liang J 

PROVIDER: S-EPMC4422653 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature