MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics.

ABSTRACT:

Purpose

MITOsym, a new mathematical model of hepatocellular respiration and bioenergetics, has been developed in partnership with the DILIsym® model with the purpose of translating in vitro compound screening data into predictions of drug induced liver injury (DILI) risk for patients. The combined efforts of these two models should increase the efficiency of evaluating compounds in drug development in addition to enhancing patient care.

Methods

MITOsym includes the basic, essential biochemical pathways associated with hepatocellular respiration and bioenergetics, including mitochondrial oxidative phosphorylation, electron transport chain activity, mitochondrial membrane potential, and glycolysis; also included are dynamic feedback signals based on perturbation of these pathw

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4422870 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature