A genetic risk score for thyroid peroxidase antibodies associates with clinical thyroid disease in community-based populations.

ABSTRACT:

Context

Antibodies against thyroid peroxidase (TPOAbs) are detected in 90% of all patients with Hashimoto thyroiditis, the most common cause of hypothyroidism. Hypothyroidism is associated with a range of adverse outcomes. The current knowledge of its genetic underpinnings is limited.

Objective

The purpose of this study was to identify novel genetic variants associated with TPOAb concentrations and positivity using genome-wide association data and to characterize their association with thyroid function and disease.

Design, setting, and participants

We studied European ancestry participants of 3 independent prospective population-based studies: Atherosclerosis Risk In Communities study (n = 7524), Study of Health in Pomerania (n = 3803), and Study of Health in Pomerani

SUBMITTER: Schultheiss UT 

PROVIDER: S-EPMC4422885 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature