Preconception low dose aspirin and time to pregnancy: findings from the effects of aspirin in gestation and reproduction randomized trial.

ABSTRACT:

Objective

The objective was to determine the effect of preconception-initiated daily low-dose aspirin (LDA; 81 mg/day) treatment on time to pregnancy in women with a history of pregnancy loss.

Design

This was a multicenter, block-randomized, double-blind, placebo-controlled trial. Participants were block-randomized by center and eligibility stratum.

Setting

The study was conducted at four U.S.A. medical centers (2007-2012).

Participants

Participants women aged 18-40 years actively attempting pregnancy, stratified by eligibility criteria: the "original" stratum, women with one loss <20 weeks' gestation during the previous year; and the "expanded" stratum, women with one or two previous losses of any gestational age regardless of time since loss.

Intervention<

SUBMITTER: Schisterman EF 

PROVIDER: S-EPMC4422888 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature