Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans.

ABSTRACT:

Context

Extracellular nucleotide receptors are expressed in pancreatic B-cells. Purinergic signaling via these receptors may regulate pancreatic B-cell function.

Objective

We hypothesized that purinergic signaling might influence glucose regulation and sought evidence in human studies of glycemic variation and a mouse model of purinergic signaling dysfunction.

Design

In humans, we mined genome-wide meta-analysis data sets to examine purinergic signaling genes for association with glycemic traits and type 2 diabetes. We performed additional testing in two genomic regions (P2RX4/P2RX7 and P2RY1) in a cohort from the Prevalence, Prediction, and Prevention of Diabetes in Botnia (n = 3504), which includes more refined measures of glucose homeostasis. In mice, we generated

SUBMITTER: Todd JN 

PROVIDER: S-EPMC4422893 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature