PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness.

ABSTRACT:

Background

The local invasion of tumor cells into the surrounding tissue is the first and most critical step of the metastatic cascade. Cells can invade either collectively, or individually. Individual cancer cell invasion can occur in the mesenchymal or amoeboid mode, which are mutually interchangeable. This plasticity of individual cancer cell invasiveness may represent an escape mechanism for invading cancer cells from anti-metastatic treatment.

Methods

To identify new signaling proteins involved in the plasticity of cancer cell invasiveness, we performed proteomic analysis of the amoeboid to mesenchymal transition with A375m2 melanoma cells in a 3D Matrigel matrix.

Results

In this screen we identified PKCα as an important protein for the maintenance of amoeboid mo

SUBMITTER: Vaskovicova K 

PROVIDER: S-EPMC4423130 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature