Convergent evolution of cysteine-rich proteins in feathers and hair.

ABSTRACT:

Background

Feathers and hair consist of cornified epidermal keratinocytes in which proteins are crosslinked via disulfide bonds between cysteine residues of structural proteins to establish mechanical resilience. Cysteine-rich keratin-associated proteins (KRTAPs) are important components of hair whereas the molecular components of feathers have remained incompletely known. Recently, we have identified a chicken gene, named epidermal differentiation cysteine-rich protein (EDCRP), that encodes a protein with a cysteine content of 36%. Here we have investigated the putative role of EDCRP in the molecular architecture and evolution of feathers.

Results

Comparative genomics showed that the presence of an EDCRP gene and the high cysteine content of the encoded proteins are conserv

SUBMITTER: Strasser B 

PROVIDER: S-EPMC4423139 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature