DNA Polymerases as targets for gene therapy of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel approaches, especially for targeted therapy, are being extensively explored. Gene therapy is ideal for such purpose for its specific expression of exogenous genes in HCC cells driven by tissue-specific promoter. However strategies based on correction of mutations or altered expressions of genes responsible for the development/progression of HCC have limitations because these aberrant molecules are not presented in all cancerous cells. In the current work, we adopted a novel strategy by targeting the DNA replication step which is essential for proliferation of every c

SUBMITTER: Liu H 

PROVIDER: S-EPMC4423151 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature