N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review.

ABSTRACT:

Objective

Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area.

Methods

PubMed, Web of Science and Cochrane Library Database were searched for human clinical trials or case reports investigating NAC in the treatment of obsessive compulsive disorder (OCD) or obsessive compulsive related disorders. Researchers with known in

SUBMITTER: Oliver G 

PROVIDER: S-EPMC4423164 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature