Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study.

ABSTRACT:

Introduction

Patients with severe sepsis often present with concurrent coagulopathy, microcirculatory failure and evidence of vascular endothelial activation and damage. Given the critical role of the endothelium in balancing hemostasis, we investigated single-point associations between whole blood coagulopathy by thrombelastography (TEG) and plasma/serum markers of endothelial activation and damage in patients with severe sepsis.

Methods

A post-hoc multicenter prospective observational study in a subgroup of 184 patients from the Scandinavian Starch for Severe Sepsis/Septic Shock (6S) Trial. Study patients were admitted to two Danish intensive care units. Inclusion criteria were severe sepsis, pre-intervention whole blood TEG measurement and a plasma/serum research sample a

SUBMITTER: Ostrowski SR 

PROVIDER: S-EPMC4423170 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature