Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity.

ABSTRACT:

Background

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are highly prevalent liver diseases that may coexist and contribute significantly to liver disease-related mortality. Obesity is a common underlying risk factor for both disorders. There has been little research investigating the combined effects of high fat diet (HFD) and alcohol. Current mouse models of alcohol- or fat-rich diet alone do not lead to severe liver injury. There is a need to develop animal models recapitulating human settings of drinking and diet to study the mechanisms of liver injury progression.

Methods

C57BL6 male mice were fed either chow or HFD ad libitum for 12 weeks. A sub-set of mice from each group were also given alcohol (2 g kg(-)(1) body weight) twice a week vi

SUBMITTER: Duly AM 

PROVIDER: S-EPMC4423200 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature