The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common and severe form of brain cancer. The median survival time of patients is approximately 12 months due to poor responses to surgery and chemoradiation. To understand the mechanisms involved in radioresistance, we conducted a genetic screen using an shRNA library to identify genes in which inhibition would sensitize cells to radiation. The results were cross-referenced with the Oncomine and Rembrandt databases to focus on genes that are highly expressed in GBM tumors and associated with poor patient outcomes. Spermidine/spermine-N1-acetyltransferase 1 (SAT1), an enzyme involved in polyamine catabolism, was identified as a gene that promotes resistance to ionizing radiation (IR), is overexpressed in brain tumors, and correlates with poor outcome

SUBMITTER: Brett-Morris A 

PROVIDER: S-EPMC4423404 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature