Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease.

ABSTRACT:

Background and aims

Inflammatory bowel diseases (IBD) are considered to be dysregulated, immune-mediated disorders; and immunosuppressive medications are the mainstay of their treatment. Clinically, we have often observed low serum immunoglobulin (Ig) levels in these patients. The aim of this study was to assess the frequency and risk factors of secondary humoral immunodeficiency in IBD patients.

Methods

We conducted a cross-sectional study of eligible IBD patients with Crohn's disease (CD), ulcerative colitis (UC), indeterminate colitis (IC) or restorative proctocolectomy with ileal pouch, who having serum Ig measured. Demographic and clinical variables were measured. Univariate and multivariate analyses were performed.

Results

A total of 324 patients was included, w

SUBMITTER: Rai T 

PROVIDER: S-EPMC4423463 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature