Natural and orthogonal model for estimating gene-gene interactions applied to cutaneous melanoma.

ABSTRACT: Epistasis, or gene-gene interaction, results from joint effects of genes on a trait; thus, the same alleles of one gene may display different genetic effects in different genetic backgrounds. In this study, we generalized the coding technique of a natural and orthogonal interaction (NOIA) model for association studies along with gene-gene interactions for dichotomous traits and human complex diseases. The NOIA model which has non-correlated estimators for genetic effects is important for estimating influence from multiple loci. We conducted simulations and data analyses to evaluate the performance of the NOIA model. Both simulation and real data analyses revealed that the NOIA statistical model had higher power for detecting main genetic effects and usually had higher power for some intera

SUBMITTER: Xiao F 

PROVIDER: S-EPMC4423532 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature