Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression.

ABSTRACT:

Context

Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant depression (TRD), but available data are limited.

Objective

To assess the efficacy and safety of subcallosal cingulate DBS in patients with TRD with either major depressive disorder (MDD) or bipolar II disorder (BP).

Design

Open-label trial with a sham lead-in phase.

Setting

Academic medical center. Patients  Men and women aged 18 to 70 years with a moderate-to-severe major depressive episode after at least 4 adequate antidepressant treatments. Ten patients with MDD and 7 with BP were enrolled from a total of 323 patients screened. Intervention  Deep brain stimulation electrodes were implanted bilaterally in the subcallosal cingulate white matter. Patients received sin

SUBMITTER: Holtzheimer PE 

PROVIDER: S-EPMC4423545 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature