A tractography analysis of two deep brain stimulation white matter targets for depression.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating depression. Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets.

Methods

Diffusion tensor imaging (DTI) and probabilistic tractography were performed in 13 nondepressed subjects to determine connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in each subject, and tract voxels were coded as being unique to either target or shared. Group level tract maps were generated by including only those voxels common to at least 10 of 13 (>75%) subjects.

Results

The two targets have distinct patterns of connectivity with regions of overlap.

SUBMITTER: Gutman DA 

PROVIDER: S-EPMC4423548 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature