Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.

ABSTRACT:

Background

The S31N amantadine-resistance mutation in the influenza A M2 sequence currently occurs more frequently in nature than the S31 wild type. Overcoming the resistance of the S31N mutation is the primary focus of M2 researchers who aim to develop novel antiviral therapies. Recent studies have noted a possible rise in frequency of the V27A/S31N double amantadine-resistance mutation in recent years. The purpose of this study is to investigate this recent rise in frequency of the double mutation and any possible bias of the other mutations toward co-occurrence with S31N or S31 strains.

Results

The primary dataset used for this study was comprised of 24,152 influenza A M2 channel sequences which were downloaded from UniProt. There is an increased frequency for the S31N/V2

SUBMITTER: Durrant MG 

PROVIDER: S-EPMC4423576 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature