Inferring alterations in cell-to-cell communication in HER2+ breast cancer using secretome profiling of three cell models.

ABSTRACT: Challenges in demonstrating durable clinical responses to molecular-targeted therapies have sparked a re-emergence in viewing cancer as an evolutionary process. In somatic evolution, cellular variants are introduced through a random process of somatic mutation and are selected for improved fitness through a competition for survival. In contrast to Darwinian evolution, cellular variants that are retained may directly alter the fitness competition. If cell-to-cell communication is important for selection, the biochemical cues secreted by malignant cells that emerge should be altered to bias this fitness competition. To test this hypothesis, we compared the proteins secreted in vitro by two human HER2+ breast cancer cell lines (BT474 and SKBR3) relative to a normal human mammary epithelial ce

SUBMITTER: Klinke DJ 

PROVIDER: S-EPMC4423606 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature