Genetic contribution to osteoarthritis development: current state of evidence.

ABSTRACT:

Purpose of review

Powerful association studies have identified a number of genetic signals that can be confidently judged as associated with osteoarthritis. Efforts have continued to discover new loci, whilst functional studies are being applied to assess which genes are the likely targets of the risk-conferring alleles. The study of epigenetics has highlighted an interaction between osteoarthritis genetics and DNA methylation. This review will summarize some of the recent key studies in osteoarthritis genetics, including functional and epigenetic analyses.

Recent findings

Several novel osteoarthritis susceptibility loci have been reported recently, including the regulatory genes NCOA3 and ALDH1A2. Functional analyses of these genes and of others reported previously support

SUBMITTER: Loughlin J 

PROVIDER: S-EPMC4423655 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature