Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4.

ABSTRACT: Toll-like receptors (TLRs) mediate immune recognition of both microbial infections and tissue damage. Aberrant TLR signaling promotes disease; thus, understanding the regulation of TLR signaling is of medical relevance. Although downstream mediators of TLR signaling have been identified, the detailed mechanism by which ligand binding-mediated dimerization induces downstream signaling remains poorly understood. Here, we investigate this question for TLR4, which mediates responsiveness to bacterial LPS and drives inflammatory disease. TLR4 exhibits structural and functional features that are unique among TLRs, including responsiveness to a wide variety of ligands. However, the connection between these structural features and the regulation of signaling is not clear. Here, we investigated how

SUBMITTER: Daringer NM 

PROVIDER: S-EPMC4423667 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature