Global transcriptome analysis reveals small RNAs affecting Neisseria meningitidis bacteremia.

ABSTRACT: Most bacterial small RNAs (sRNAs) are post-transcriptional regulators involved in adaptive responses, controlling gene expression by modulating translation or stability of their target mRNAs often in concert with the RNA chaperone Hfq. Neisseria meningitides, the leading cause of bacterial meningitis, is able to adapt to different host niches during human infection. However, only a few sRNAs and their functions have been fully described to date. Recently, transcriptional expression profiling of N. meningitides in human blood ex vivo revealed 91 differentially expressed putative sRNAs. Here we expanded this analysis by performing a global transcriptome study after exposure of N. meningitides to physiologically relevant stress signals (e.g. heat shock, oxidative stress, iron and carbon sourc

SUBMITTER: Fagnocchi L 

PROVIDER: S-EPMC4423775 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature