Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial.

ABSTRACT:

Importance

Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure is unknown.

Objective

To examine whether intensive therapy for hypertension and combination therapy with a statin plus a fibrate reduces the risk of decline in cognitive function and total brain volume (TBV) in patients with T2DM.

Design, setting, and participants

A North American multicenter clinical trial including 2977 participants without baseline clinical evidence of cognitive impairment or dementia and with h

SUBMITTER: Williamson JD 

PROVIDER: S-EPMC4423790 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature