Networks in Coronary Heart Disease Genetics As a Step towards Systems Epidemiology.

ABSTRACT: We present the use of innovative machine learning techniques in the understanding of Coronary Heart Disease (CHD) through intermediate traits, as an example of the use of this class of methods as a first step towards a systems epidemiology approach of complex diseases genetics. Using a sample of 252 middle-aged men, of which 102 had a CHD event in 10 years follow-up, we applied machine learning algorithms for the selection of CHD intermediate phenotypes, established markers, risk factors, and their previously associated genetic polymorphisms, and constructed a map of relationships between the selected variables. Of the 52 variables considered, 42 were retained after selection of the most informative variables for CHD. The constructed map suggests that most selected variables were related t

SUBMITTER: Drenos F 

PROVIDER: S-EPMC4423836 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature