Arterial Hypertension Is Characterized by Imbalance of Pro-Angiogenic versus Anti-Angiogenic Factors.

ABSTRACT:

Objective

Hypertension is the most common cardiovascular disease and the main risk factor for stroke, peripheral arterial disease, arterial aneurysms and kidney disease. It has been reported recently that hypertensive patients and animals are characterized by decreased density of arterioles and capillaries in the tissues, called rarefaction. Rarefaction significantly increases peripheral resistance which results in elevated blood pressure, leads to vessel damage and induction of inflammation. Therefore, we hypothesized that hypertension is associated with decreased serum concentration of physiological pro-angiogenic factors and concomitant increased production of angiogenesis inhibitors.

Materials and methods

82 patients diagnosed with hypertension and 34 healthy volunteers

SUBMITTER: Marek-Trzonkowska N 

PROVIDER: S-EPMC4423857 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature