Diagnostic value of osteopontin in ovarian cancer: a meta-analysis and systematic review.

ABSTRACT:

Aims

Osteopontin (OPN) plays an important role in many physiological and pathological processes (wound healing, inflammation, immune response, and tumorigenesis). This meta-analysis assessed the diagnostic value of osteopontin in ovarian cancer.

Methods and results

Searches in Embase and PubMed were conducted, in order to identify eligible studies on osteopontin expression and its diagnostic value in ovarian cancer. The revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tool was applied to examine the quality of these studies and the overall osteopontin diagnostic accuracy in ovarian cancer was pooled using the bivariate model. The publication bias was assessed using funnel plots and Deek's test. This search methodology resulted in 13 studies with a tot

SUBMITTER: Hu ZD 

PROVIDER: S-EPMC4423864 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature