Head injury does not alter disease progression or neuropathologic outcomes in ALS.

ABSTRACT:

Objectives

To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS).

Methods

Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predictor for mean monthly decline of Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-R), while controlling for confounders. Head injury history was obtained from family members of ALS autopsy cases. The frequency of tau proteinopathy, brain TDP-43 inclusions, and pathologic findings of Alzheimer disease (AD) were examined in ALS cases with head injury compared to cases without. Logistic regression was performed with each neuropathologic diagnos

SUBMITTER: Fournier CN 

PROVIDER: S-EPMC4424128 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature