Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis.

ABSTRACT:

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Studies indicate that improving sleep decreases reported pain in patients with knee osteoarthritis, but it is unclear if this association extends to experimentally induced pain responses. A community-based sample of 88 African American and 52 non-Hispanic white adults (45-76 years) with knee osteoarthritis completed the Insomnia Severity Index and the arousal subscale of the Sleep Hygiene and Practices Scale. Participants underwent quantitative sensory testing, including measures of pain sensitivity and facilitation at the knee, and pain inhibition. Outcomes were analyzed with multiple Tobit hierarchical regression models, with adjustment for relevant covariates. Ethnicity and sex by sleep interactions were also entered into the models. After covariate adjustment, main a

SUBMITTER: Petrov ME 

PROVIDER: S-EPMC4424160 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature