The impact of adiposity on adipose tissue-resident lymphocyte activation in humans.

ABSTRACT:

Background/objectives

The presence of T lymphocytes in human adipose tissue has only recently been demonstrated and relatively little is known of their potential relevance in the development of obesity-related diseases. We aimed to further characterise these cells and in particular to investigate how they interact with modestly increased levels of adiposity typical of common overweight and obesity.

Subjects/methods

Subcutaneous adipose tissue and fasting blood samples were obtained from healthy males aged 35-55 years with waist circumferences in lean (<94 cm), overweight (94-102 cm) and obese (>102 cm) categories. Adipose tissue-resident CD4+ and CD8+ T lymphocytes together with macrophages were identified by gene expression and flow cytometry. T lymphocytes were further cha

SUBMITTER: Travers RL 

PROVIDER: S-EPMC4424387 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature