Regulatory networks in retinal ischemia-reperfusion injury.

ABSTRACT:

Background

Retinal function is ordered by interactions between transcriptional and posttranscriptional regulators at the molecular level. These regulators include transcription factors (TFs) and posttranscriptional factors such as microRNAs (miRs). Some studies propose that miRs predominantly target the TFs rather than other types of protein coding genes and such studies suggest a possible interconnection of these two regulators in co-regulatory networks.

Results

Our lab has generated mRNA and miRNA microarray expression data to investigate time-dependent changes in gene expression, following induction of ischemia-reperfusion (IR) injury in the rat retina. Data from different reperfusion time points following retinal IR-injury were analyzed. Paired expression data for miRNA-

SUBMITTER: Andreeva K 

PROVIDER: S-EPMC4424502 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature