Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis.

ABSTRACT:

Background

Duchenne Muscular Dystrophy (DMD) is an X-linked recessive disorder with its primary insult on the skeletal muscle. Severe muscle wasting, chronic inflammation and fibrosis characterize dystrophic muscle. Here we identify dysregulated pathways in DMD utilizing a co-expression network approach as described in Weighted Gene Co-expression Network Analysis (WGCNA). Specifically, we utilize WGCNA's "preservation" statistics to identify gene modules that exhibit a weak conservation of network topology within healthy and dystrophic networks. Preservation statistics rank modules based on their topological metrics such as node density, connectivity and separability between networks.

Methods

Raw data for DMD was downloaded from Gene Expression Omnibus (GSE6011) and suitably

SUBMITTER: Mukund K 

PROVIDER: S-EPMC4424514 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature