Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis.

ABSTRACT:

Background

Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilised cancer cell lines or clinical samples, where it is difficult to identify the initial epigenetic lesions from those that occur over time. Here, we analysed the epigenome of human mammary epithelial cells (HMEC) and a matched variant cell population (vHMEC) that have spontaneously escaped senescence and undergone partial carcinogenic transformation. Using this model of basal-like breast carcinogenesis, we provide striking new insights into the very first epigenetic changes that occur during the initial stages of malignancy.

Results

The first phase of maligna

SUBMITTER: Locke WJ 

PROVIDER: S-EPMC4424562 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature