Development of a comparative genomic fingerprinting assay for rapid and high resolution genotyping of Arcobacter butzleri.

ABSTRACT:

Background

Molecular typing methods are critical for epidemiological investigations, facilitating disease outbreak detection and source identification. Study of the epidemiology of the emerging human pathogen Arcobacter butzleri is currently hampered by the lack of a subtyping method that is easily deployable in the context of routine epidemiological surveillance. In this study we describe a comparative genomic fingerprinting (CGF) method for high-resolution and high-throughput subtyping of A. butzleri. Comparative analysis of the genome sequences of eleven A. butzleri strains, including eight strains newly sequenced as part of this project, was employed to identify accessory genes suitable for generating unique genetic fingerprints for high-resolution subtyping based on gene prese

SUBMITTER: Webb AL 

PROVIDER: S-EPMC4424573 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature