The in ovo conversion of oestrone to oestrone sulfate is rapid and subject to inhibition by Bisphenol A.

ABSTRACT: Vertebrate embryos develop in the presence of maternally derived steroids. While these steroids can influence development, embryonic enzymes are thought to buffer some steroid sensitive processes, such as gonadal differentiation, from the effects of maternal steroids. Many of these same enzymes may also buffer the embryo from chemicals present in the environment, but this may alter their capacity to metabolize maternal steroids. Here, we characterized the ability of red-eared slider (Trachemys scripta) embryos to metabolize oestrone immediately following oviposition and tested whether a prevalent environmental chemical, Bisphenol A (BPA), would affect the in ovo conversion of oestrone to oestrone sulfate. We found that tritiated oestrone applied at the time of oviposition is mostly convert

SUBMITTER: Paitz RT 

PROVIDER: S-EPMC4424608 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature