Investigating biomechanical noise in neuroblastoma cells using the quartz crystal microbalance.

ABSTRACT: Quantifying cellular behaviour by motility and morphology changes is increasingly important in formulating an understanding of fundamental physiological phenomena and cellular mechanisms of disease. However, cells are complex biological units, which often respond to external environmental factors by manifesting subtle responses that may be difficult to interpret using conventional biophysical measurements. This paper describes the adaptation of the quartz crystal microbalance (QCM) to monitor neuroblastoma cells undergoing environmental stress wherein the frequency stability of the device can be correlated to changes in cellular state. By employing time domain analysis of the resulting frequency fluctuations, it is possible to study the variations in cellular motility and distinguish betwe

SUBMITTER: Prasad A 

PROVIDER: S-EPMC4424671 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature