Optimal control strategies of eradicating invisible glioblastoma cells after conventional surgery.

ABSTRACT: Glioblastoma, the most aggressive type of brain cancer, has median survival time of 1 year after diagnosis. It is characterized by alternating modes of rapid proliferation and aggressive invasion in response to metabolic stress in the microenvironment. A particular microRNA, miR-451, and its downstream signalling molecules, AMPK complex, are known to be key determinants in switching cell fate. These components form a core control system determining a balance between cell growth and migration which is regulated by fluctuating glucose levels in the microenvironment. An important factor from the treatment point of view is that low levels of glucose affect metabolism and activate cell migration through the miR-451-AMPK control system, creating 'invisible' migratory cells and making them inacce

SUBMITTER: de Los Reyes V AA 

PROVIDER: S-EPMC4424672 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature