Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation.
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ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC4424975 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation.
Zhang Peng P Riazy Maziar M Gold Matthew M Tsai Shu-Huei SH McNagny Kelly K Proud Christopher C Duronio Vincent V
The Canadian journal of cardiology 20140928 12
We tested whether loss of eukaryotic elongation factor 2 kinase (eEF2K) activity in macrophages suppresses development of atherosclerosis by transplanting bone marrow from mice with mutant eEF2K into ldlr(-/-) mice. Sixteen weeks after high-fat diet feeding, mutant eEF2K hematopoietic chimeras had a dramatically reduced level of atherosclerotic plaque formation. M1-skewed macrophages from eEF2K knock-in mice have less tumour necrosis factor-α release and a lesser ability to induce expression of ...[more]
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