Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis.

ABSTRACT:

Background & aims

Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations in patient assessments of disease severity. We also evaluated relationships between patient assessment of disease severity and EoE-associated endoscopic, histologic, and laboratory findings.

Methods

We collected information from 186 patients with EoE in Switzerland and the United States (69.4% male; median age, 43 y) via surveys (n = 135), focus groups (n = 27), and semistructured interviews (n = 24). Items were generated for the instruments to assess biologic

SUBMITTER: Schoepfer AM 

PROVIDER: S-EPMC4425255 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature