Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration.

ABSTRACT: Recognition of nonverbal sounds in semantic dementia and other syndromes of anterior temporal lobe degeneration may determine clinical symptoms and help to define phenotypic profiles. However, nonverbal auditory semantic function has not been widely studied in these syndromes. Here we investigated semantic processing in two key nonverbal auditory domains - environmental sounds and melodies - in patients with semantic dementia (SD group; n=9) and in patients with anterior temporal lobe atrophy presenting with behavioural decline (TL group; n=7, including four cases with MAPT mutations) in relation to healthy older controls (n=20). We assessed auditory semantic performance in each domain using novel, uniform within-modality neuropsychological procedures that determined sound identification b

SUBMITTER: Golden HL 

PROVIDER: S-EPMC4425361 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature